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New Generation Facial Wrinkle Filler

AestheFill®

AestheFill® (PDLLA, poly-D, L-lactic acid) is an injectable dermal filler to improve facial wrinkles and folds through collagen stimulation. It fills the injected spaces and maintains the initial volume for a certain period of time. The effectiveness and safety had been proved by clinical study. [2]


Collagen is an essential scaffold protein that gives smoothness and elasticity to skin, but its production declines with age. Skin aging results from a series of divergent processes which affect many constituents of the skin and hence its appearance. [1]


Injectable PDLLA is a biocompatible, biodegradable, biostimulatory and long-lasting substance that is used as a new soft tissue filler. It also has a short reconstitution time, needs little water for reconstitution, and has a lower complication rate compared with PLLA. [3]

PRODUCT MAY NOT BE AVAILABLE IN ALL COUNTRIES. INTENDED USE MAY VARY FROM COUNTRY TO COUNTRY.

PLEASE ALWAYS REFER TO THE PRODUCT INFORMATION APPROVED IN YOUR COUNTRY.


References:

[1] Skin collagen through the life stages: importance for skin health and beauty. Reilly et al. Plast Aesthet Res 2021;8:2

[2] AestheFill Clinical Study Report_2014

[3] Injectable Poly-D, L-lactic Acid in Facial Rejuvenation: Three Case Reports. Jui-Yu Lin and Chuan-Yuan Lin. Cosmetol J 2020, 4(1): 000120.

3S / 3N 

Simple / Safe / Satisfactory Procedure

No Incision / No Suture / No Bleeding

Safe Filler 

PLA is a safe and US FDA-approved

substance under its GRAS(Generally

Recognized as Safe) registration since 1984

Natural Volume 

By actively stimulating production of new collagen and tissues, AestheFill® can correct wrinkles and folds, volumize the overall facial areas, and keep a more natural volume for a long time.

Long-lasting Volume

Longer-lasting neocollagenesis. Slowly degradation or absorption in the body. Volume results up to 2 years.

Biodegradable Filler

PDLLA is excreted outside the body after being decomposed into water and carbon dioxide 

(H2O and CO2)

Simple Procedure 

The patient can return to normal daily life 1-2 hours after the procedure

Treatment Areas

Reconstitution

1. Wipe the rubber stopper of the vial with an alcohol swab.

2. Prepare a 10ml sterile disposable syringe with an 18G needle.

3. Draw 8ml sterile water in the 10ml disposable syringe (do not use normal saline since it will make the dilution take much more time)

4. Insert the 18G needle into the vial, and inject the sterile water slowly along the side of the via. Pain may be reduced by mixing 2ml Lidocain

5. Shake the vial lightly in a circular motion to dissolve the solution evenly

6. Before injection, take a new sterile disposable syringe and place it on a 18G needle, then draw the solution into the syringe

Injection Techniques

Linear

Areas : Eyebrow ridge, jaw line, Neck lines

Depth : Sub-cutaneous layer

  • Full length of the needle is inserted beneath skin, and AestheFill® is injected while pulling the needle slowly backwards so that AestheFill is placed lengthwise beneath skin.
Depot

Areas : Temples, malar region

Depth : Supra-periosteum

  • Small bolus: 0.2mL (label) Emerging opinion from expert injectors suggest. -> 0.5 ml per depot injection
  • Perform a reflux maneuver.
  • Injections spaced 0.5-1.0 cm -> (2 to 6 injections per side approx)
Fan

Areas: Mid Face, Upper Face, Lower Face, Submental, Submandibula

  • AestheFill® should be injected into the deep dermis or subcutaneous layer.
  • Always perform a reflux maneuver prior to injection.
  • 25 G cannula, 1-3 ml syringe.

Before and After

Case 1

Case 2

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Reference: REGEN Biotech, Inc. Clinical Study Report